413 Role of calcitonin gene-related peptide in atopic dermatitis
نویسندگان
چکیده
Atopic dermatitis (AD) is an often severely pruritic chronic inflammatory disease worsened by psychological stress. Calcitonin gene-related peptide (CGRP) a sensory neuropeptide, which may cause pruritus. Earlier studies indicate special pathogenetic role for CGRP in AD. However, somewhat contradictory results regarding positive nerve fibers AD skin, have been reported. We studied skin biopsies from 26 patients with The were taken lesional and non-lesional addition, normal 10 healthy individuals investigated expression of CGRP, using biotinylated–streptavidine technique fluorescence microscopy. total number was highest the which, contrast to also had intraepidermal nerve-like structures CGRP. Some showed sprouting papillary dermis. In there cells, while just few such cells skin. keratinocyte could be found. These support process that nerves are involved.
منابع مشابه
Comparison between Brain Natriuretic Peptide and Calcitonin Gene Related Peptide in Children with Dilated Cardiomyopathy
Background: Dilated cardiomyopathy (DCM) is revealed with the left ventricular dilatation and systolic dysfunction. This study was performed to determine the level of Calcitonin Gene Related Peptide (CGRP) and Brain Natriuretic Peptide (BNP) in children with dilated cardiomyopathy and controls and comparison of these two biomarkers in patients. Materials and Methods: This case-control study was...
متن کاملCalcitonin Gene-Related Peptide (CGRP)
Calcitonin gene-related peptide (CGRP) is a 37 amino acid vasoactive neuropeptide that is widely distributed in central and peripheral nervous systems in mammals. CGRP was discovered in 1982 by molecular cloning of calcitonin (CT) gene. CGRP-specific mRNA appears to predominate in the hypothalamus while CT mRNA predominates in the thyroid. CGRP has an amphiphilic α-helical secondary structure i...
متن کاملCalcitonin gene-related peptide: functional role in cerebrovascular regulation.
Distribution studies disclosed that all major cerebral arteries and cortical arterioles of the cat were invested with fine varicose nerve fibers that contained calcitonin gene-related peptide (CGRP)-like immunoreactivity; the trigeminal ganglia likewise contained CGRP immunoreactivity. Sequential immunostaining with antibodies to CGRP and to substance P (SP) revealed identical distributions of ...
متن کاملCalcitonin gene-related peptide and its role in migraine pathophysiology.
Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide released from activated trigeminal sensory nerves, dilates intracranial blood vessels and transmits vascular nociception. Therefore, it is propounded that: (i) CGRP may have an important role in migraine pathophysiology, and (ii) inhibition...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.09.426